Chronic Lymphocytic Leukemia: A Hazardous Condition Before Kidney Transplantation

Stem cell transplantation in chronic lymphocytic leukemia.

Chronic lymphocytic leukemia (CLL) remains incurable with standard therapy. Most patients with CLL have an indolent clinical course, but it is possible to identify patients with high-risk disease. Younger patients with adverse risk factors will die from their disease, and are therefore candidates for clinical trials exploring hematopoietic stem cell transplantation (HSCT). Autologous SCT is fea...

Stem Cell Transplantation in Chronic Lymphocytic Leukemia

Allogeneic Transplantation for Chronic Lymphocytic Leukemia

Even if Chronic lymphocytic leukemia (CLL) often has an indolent behavior with good responsiveness to cytoreductive treatment, about 20% of the patients, so called "poor-risk" patients, show an aggressive course and die within a few years despite early intensive therapies. Criteria for poor-risk disease according to the European Bone Marrow Transplantation (EBMT) CLL Transplant Consensus are: p...

Chronic lymphocytic leukemia: new choices for an old condition.

The role of microRNA in acute/chronic, myeloid/lymphocytic leukemia

MicroRNAs are small, non-coding sequences that regulate gene expression by inducing degradation or translational inhibition of target mRNAs. These molecules control many intracellular physiological and pathological processes.Abnormal expression of these moleculs has been described in different cancers including hematopoietic cancers. According to the type of cancer and the stage, miRNA’s expres...